J. Preciado, T. Lam, S.M. Azarin, E. Lou, A. Aksan, 2021 “Induction of dormancy by confinement: An agarose‐silica biomaterial for isolating and analyzing dormant cancer cells” Journal of Biomedical Materials Research B Applied Biomaterials.


T. Lam, J.A. Aguirre-Ghiso, M.A. Geller, A. Aksan, S. Azarin, 2020 “Immobilization rapidly selects for chemoresistant ovarian cancer cells with enhanced ability to enter dormancyBiotechnology and Bioengineering,


B.J. Jones, A. Mahajan, A. Aksan, 2019 “Dextranol: An Inert XeroprotectantPlosONE, 14, 9, e0222006.

S. Jena, K. Kumar, A. Aksan, R. Suryanarayanan, 2019 “Stability of Lyophilized Albumin Formulation: Role of Excipient Crystallinity and Molecular Mobility” International Journal of Pharmaceutics, 569, 5, 118568.

D. Escalante, A. Aksan, 2019 “Role of Water Hydrogen Bonding on Transport of Small Molecules Inside Hydrophobic Channels” Journal of Physical Chemistry B 123, 31, 6673-6685

D. Escalante, A. Aksan, 2019 “Prediction of Ligand Transport along Hydrophobic Enzyme Nanochannels” Computational and Structural Biotechnology Journal, 17, 757-760. 

M. Schwabs, C. Bergonzi, J.K. Sakkos, C. Staley, Q. Zhang, M.J. Sadowsky, A. Aksan, M. Elias 2019 “Signal Disruption Leads to Changes in Bacterial Community Population" Frontiers in Microbiology, 10, Article #611. 

J.K. Sakkos, L.P. Wackett, A. Aksan, 2019 “Enhancement of Biocatalyst Activity and Protection Against Stressors Using a Microbial Exoskeleton” Scientific Reports 9, 3158. 

M. Wang, J.O.M. Karlsson, A. Aksan, 2019 “FTIR Analysis of Molecular Changes Associated with Warming Injury in Cryopreserved Leukocytes” Langmuir 35, 23, 7552-7559.

J. Horn, S. Jena, A. Aksan, W. Friess, 2019 “Freeze/Thaw of IGG Solutions” European Journal of Pharmaceutics and Biopharmaceutics, 134, 185-189.


B.J. Jones, A. Mahajan, A. Aksan, 2018 “Dextranol: A better lyoprotectant” BioRxiv (preprint available at:

J.J. Benson, J. Sakkos, A. Radian, L.P. Wackett, A. Aksan, 2018 “Enhanced Biodegradation of Atrazine by Bacteria Encapsulated in Organically Modified Silica Gels” Journal of Colloid & Interface Science, 510, 57-68.


S. Jena, A. Aksan, 2017 “Effect of High DMSO Concentration on Albumin during Freezing and Vitrification” RSC Advances, 7, 43611-43620.

J.A. Preciado, E. Reategui, S.M. Azarin, E. Lou, A. Aksan, 2017 “Immobilization Platform to Select and Induce Quiescence in Dormancy-Capable Cancer Cells” Technology, 5, 3, 129-138.

J. Sakkos, B.R. Mutlu, L.P. Wackett, A. Aksan, 2017 “Adsorption and Biodegradation of Aromatic Chemicals by Bacteria Encapsulated in a Hydrophobic Silica Gel” ACS Applied Materials and Interfaces, 9, 26848–26858.

D. Escalante, K. Aukema, L.P. Wackett, A. Aksan, 2017 “Simulation of the Bottleneck Controlling Access into a Rieske Active Site: Predicting Substrates of Naphthalene 1,2-Dioxygenase” Journal of Chemical Information and Modeling 57, 550–561.

K. Aukema, D. Escalante, M. Maltby, A. Bera, A. Aksan, L.P. Wackett, 2017 “Identification of Bioremediation Potential: Carbamazepine and Other Recalcitrant Personal Care Products” Environmental Science and Technology 51, 880–888.

S. Jena, J. Horn, R. Suryanarayanan, W. Friess, A. Aksan, 2017 “Effects of excipient interactions on the state of the freeze-concentrate and protein stability” Pharmaceutical Research34, 462-478.


A.L. Prieto, L.H. Sigtermans, B.R. Mutlu, A. Aksan, W.A. Arnold, P.J. Novak, 2016 “Performance of a composite bioactive membrane for H2production and capture from high strength wastewater” Environmental Science: Water Research & Technology, 2, 848 - 857.

J.J. Benson, L.P. Wackett, A. Aksan, 2016 “Production of monodisperse silica gel microspheres for bioencapsulation by extrusion into an oil crossflow” Journal of Microencapsulation, 33,5, 412-420.

B.R. Mutlu, J.K. Sakkos, S. Yeom, L.P. Wackett, A. Aksan, 2016 “Silica ecosystem for synergistic biotransformation” Scientific Reports, 6, 27404. 

M.J. Solivio, R. Less, M. Rynes, M. Kramer, A. Aksan, 2016 “Adsorbing/dissolving Lyoprotectant Matrix Technology for Non-cryogenic Storage of Archival Human Sera” Scientific Reports, 6, 24186.

S. Jena, R. Suryanarayanan, A. Aksan, 2016 “­­Mutual influence of mannitol and trehalose on crystallization behavior in frozen solutions” Pharmaceutical Research,33, 1413-1425.

J.K. Sakkos, D.P. Kieffer, B.R. Mutlu, L.P. Wackett, A. Aksan, 2016 “Engineering of a Silica Encapsulation Platform for Hydrocarbon Degradation Using Pseudomonas sp.NCIB 9816-4,” Biotechnology and Bioengineering, 113, 513-521. 


A. Radian, K. Aukema, A. Aksan, L.P. Wackett, 2015 “A Silica Gel for Enhanced Activity and Hypochlorite-Protection of Cyanuric Acid Hydrolase in Recombinant E. coli” mBio, 6, e01477-15.

S. Yeom, B.R. Mutlu, A. Aksan, L.P. Wackett, 2015 “Bacterial Cyanuric Acid Hydrolase for Water Treatment,” Applied and Environmental Microbiology, 81, 6660-6668.

A. Twomey, K. Kurata, Y. Nagare, H. Takamatsu, A. Aksan, 2015 “Microheterogeneity in Frozen Protein Solutions” International Journal of Pharmaceutics,87, 91-100. 

B.R. Mutlu, K. Hirschey, L.P. Wackett, A. Aksan, 2015 “Long-Term Preservation of Silica Gel Encapsulated Bacterial Biocatalysts by Desiccation,” Journal of Sol-Gel Science and Technology, 74, 823-833. 

B.R. Mutlu, S. Yeom, L.P. Wackett, A. Aksan, 2015 “Modelling and Optimization of a Bioremediation System Utilizing Silica Gel Encapsulated Whole-Cell Biocatalyst,” Chemical Engineering Journal, 259, 574-580.


E. Reátegui, L. Kasinkas, K. Kniesz, M.A. Lefebvre, A. Aksan, 2014 “Silica-PEG Immobilization of Mammalian Cells,”Journal of Materials Chemistry B, 2, 7440-7448.

A. Abazari, N. Chakraborty, S. Hand, A. Aksan, M. Toner, 2014 “A Raman Microspectroscopy Study of Water and Trehalose in Spin-Dried Cells,” Biophysical Journal,107, 2253-2262.

K.G. Akuema, L. Kasinkas, A. Aksan, L.P. Wackett, 2014 “Use of Silica-Encapsulated Pseudomonas sp Strain NCIB 9816-4 in Biodegradation of Novel Hydrocarbon Ring Structures Found in Hydraulic Fracturing Waters”,Applied and Environmental Microbiology,80, 16, 4968-4976.

H.-W. Tong, B.R. Mutlu, L.P. Wackett, A. Aksan, 2014 “Manufacturing of Bioreactive Nanofibers for Bioremediation,” Biotechnology and Bioengineering, 111, 8, 1483-1493

L. C. Strong, T. Gould, L. Kasinkas, M. J. Sadowsky, A. Aksan, L.P. Wackett, 2014 “Biodegradation in Produced Waters: Chemistry, Microbiology and Engineering” Journal of Environmental Engineering,B4013001

H.-W. Tong, B.R. Mutlu, L.P. Wackett, A. Aksan, 2013 “Silica/PVA Biocatalytic Nanofibers” Materials Letters, 111, 234-237.

B.R. Mutlu, S. Yeom, H.-W. Tong, L. R. Wackett, A. Aksan, 2013 “Silicon Alkoxide Cross-Linked Silica Nanoparticle Gels for Encapsulation of Bacterial Biocatalysts” Journal of Materials Chemistry A, 1,36, 11051 - 11060.

A. Twomey, R. Less, K. Kurata, H. Takamatsu,A. Aksan, 2013 “In Situ Spectroscopic Quantification of Protein-Ice Interactions” Journal of Physical Chemistry B, 117, 26, 7889-7897.

R. Less, K.L.M. Boylan, A.P.N. Skubitz, A. Aksan, 2013 “Isothermal Vitrification Methodology Development for Non-cryogenic Storage of Archival Human Sera” Cryobiology,66,176–185.

V. Ragoonanan, R. Less, A. Aksan, 2013 “Response of the cell membrane-cytoskeleton complex to osmotic and freeze/thaw stresses Part 2: The link between the structure of the membrane-cytoskeleton complex and cellular damage” Cryobiology66, 96–104.

E. Reategui, E. Reynolds, L. Kasinkas, A. Aggrawal, M. Sadowsky, A. Aksan, L.P. Wackett, 2012 “Silica Gel Encapsulated AtzA Biocatalyst for Atrazine Biodegradation,” Applied Microbiology and Biotechnology, 96, 231-240.

N. Chakraborty, M.A. Menze, J. Malsam, A. Aksan, S.C. Hand, M. Toner, 2011 “Cryopreservation of Spin-Dried Mammalian Cells,” PLoS One, 6,9, e24916.

A. Hubel, A. Aksan, A.P.N. Skubitz, C. Wendt, X. Zhong, 2011 “State of the Art in Preservation of Fluid Biospecimens, Biopreservation and Biobanking, 9,3, 237–244.

V. Ragoonanan, T. Wiedmann, A. Aksan, 2010 “Characterization of the Effect of NaCl and Trehalose on the Thermotropic Hysteresis of DOPC Lipids during Freeze/Thaw” Journal of Physical Chemistry B,114,50, 16752–16758.

V. Ragoonanan, A. Hubel, A. Aksan, 2010 “Freeze-Thaw Response of the Cell Membrane and the Cytoskeleton” Cryobiology,61,335-344.

J. Dong, J. Malsam, J.C. Bischof, A. Hubel, A. Aksan, 2010 “Spatial Distribution of the State of Water in a Frozen Mammalian Cell” Biophysical Journal, 99, 8, 2453–2459. 

E. Reategui, A. Aksan, 2010, “Effects of Water on the Structure and Low/High Temperature Stability of Confined Proteins,” Physical Chemistry Chemical Physics, 12, 10161-10172.

A. Aksan, J.J. McGrath, 2010, “Acute Recovery of Patellar Tendon from Heat-induced Shrinkage and Its Inhibition by Mild Cross-linking,” ASME Journal of Biomechanical Engineering, 132, 9,091007.

B. Jo, A. Aksan, 2010, “Prediction of the Extent of Thermal Damage in the Cornea during Conductive Keratoplasty,” Journal of Thermal Biology, 35, 4, 167-174.

J. Malsam, A. Aksan, 2010, “Hydrogen Bonding Kinetics and Compartmentalization of Water in Supercooled Aqueous Acetone Solutions,” Journal of Physical Chemistry B, 114,12, 4238–4245.

L. Zhang, A. Aksan, 2010, “Thermal Modification of Human Cornea Tissue by Conductive Keratoplasty,” Applied Spectroscopy, 64, 1, 23-29.

C. Scherber, J. Schottel, A. Aksan, 2009, “Membrane Phase Behavior of Escherichia coli during Desiccation, Rehydration and Growth Recovery” Biochimica et Biophysica Acta, 1788, 2427-2435.

E. Reategui,A. Aksan, 2009, “Effects of the Kinetic and Thermodynamic Transitions of Confined Water on the Structures of Isolated and Cytoplasmic Proteins,” Journal of Physical Chemistry B, 113, 39, 13048-13060.

A. Aksan, A. Hubel, J. Bischof, 2009, “Molecular-Level Phenomena in Biotransport” ASME Journal of Biomechanical Engineering, 131, 074004.

E. Reategui, A. Aksan, 2009, “Structural Changes in Confined Lysozyme,” ASME Journal of Biomechanical Engineering, 131, 074520.

J. Dong, A. Hubel, J. Bischof, A. Aksan, 2009, “Freezing-Induced Phase Separation and Spatial Microheterogeneity in Protein Solutions,” Journal of Physical Chemistry B, 113, 30, 10081-10087.

J. Malsam, A. Aksan, 2009, “Hydrogen Bonding Kinetics of Water in High Concentration Trehalose Solutions at Cryogenic Temperatures,” Journal of Physical Chemistry B, 113, 19, 6792-6799.

A. Aksan, A. Hubel, 2008, “Biopreservation of Cells for Use in Biotechnology and Cell Therapy,” Bioprocessing Journal, 7, 4, 43-47.

V. Ragoonanan, J. Malsam, D.R. Bond, A. Aksan, 2008, “Membrane Phase Change during Drying Determines the Viability of Geobacter sulfurreducens,” Biochimica et Biophysica Acta, 1778, 10, 2283-2290.

A. Aksan, A. Hubel, J.C. Bischof, 2008, “The Role of Water at Multiple Scales in Biotransport,” Journal of the Japan Society of Mechanical Engineers, 111, 1076, 598-600.

T. Stylianopoulos, A. Aksan, V. H. Barocas, 2008, “A Structural, Kinetic Model of Soft Tissue Thermomechanics,” Biophysical Journal, 94, 3, 717-725.

V. Ragoonanan, A. Aksan, 2008, “Heterogeneity in Desiccated Solutions: Implications for Biostabilization,” Biophysical Journal, 94, 6, 2212-2227.

V. Ragoonanan, A. Aksan, 2007, “Preservation of Proteins: A Review,” Transfusion Medicine and Hemotherapy34, 246-252.

M.C. Flickinger, J.L. Schottel, D.R. Bond, A. Aksan, L.E. Scriven, 2007, “Painting and Printing Living Bacteria: Engineering Nanoporous Biocatalytic Coatings to Preserve Microbial Viability and Intensify Reactivity,” Biotechnology Progress23, 2-17. 

M.M. Norris, A. Aksan, K. Sugimachi, M. Toner, 2006, “3-O-Methyl-D-Glucose Improves Desiccation Tolerance of Keratinocytes,”Tissue Engineering, 12, 7, pp.1873-1879.

A. Aksan, D. Irimia, X. He, M. Toner, 2006 “Vitrification of Carbohydrate Solutions in Microchannels,” Journal of Applied Physics, 99, 6, 064703.

X-H. Liu, A. Aksan, M. A. Menze, S. C. Hand, M. Toner, 2005, “Trehalose Loading Through the Mitochondrial Permeability Transition Pore Enhances Desiccation Tolerance in Rat Liver Mitochondria,” Biochimica et Biophysica Acta, 1717, pp.21-26.

A. Aksan,S.C. Morris, M. Toner, 2005, “Analysis of Desiccation and Vitrification Characteristics of Carbohydrate Films by Shear-Wave Resonators,” Langmuir,21, 7, pp. 2847-2854.

A. Aksan, J.J. McGrath, D.S. Nielubowicz, 2005, “Thermal Damage Prediction for Collagenous Tissues, Part I: A Clinically Relevant Numerical Simulation Incorporating Heating Rate Dependent Denaturation,” ASME Journal of Biomechanical Engineering, 127, pp 85-97.

A. Aksan, M. Toner, 2004, “Isothermal Drying Kinetics and Vitrification of Trehalose-Dextran Solutions,” Langmuir,20, 13, pp. 5521-5529.

A. Aksan, J.J. McGrath, 2003, “Thermomechanical Analysis of Soft Tissue Thermo-therapy,” ASME Journal of Biomechanical Engineering, 125, pp.700-708.

A. Aksan, J.J. McGrath, 2002, “Effects of Thermal Damage on the Mechanical Properties of Collagenous Tissues,” Technology and Health Care, 10, No.3-4, pp.281-283.

S.P. Arnoczky, A. Aksan, 2000, “Thermal Modification of Connective Tissues: Basic Science Considerations and Clinical Implications,” Journal of the American Academy of Orthopaedic Surgeons, 8, 5, pp. 305-313.